The Grand Hotel Santa Lucia offers 97 guestrooms including 8 junior suites, 4 suites and a Presidential Penthouse Suite. All guestrooms, junior suites and suites are equipped air conditioning, cable and satellite TV, radio, direct dial telephone, high speed internet, modem, dataport, safe, minibar and bathroom with bathtub/shower, hairdryer and toiletries.
- The Classic Rooms are situated in the internal or lateral wing of the hotel in a quiet location. These rooms are decorated stylishly with modern comfort.
- The Superior Rooms are mansard guestrooms situated in the internal or lateral wing of the hotel in a quiet location. These spacious rooms are elegantly decorated in biedermeier style with fabrics in warm Mediterranean colours. The bathrooms are tiled with green Guatemalan marble.
- The Deluxe Rooms are spacious rooms and they are individually decorated in Directoire or Biedermeier style with elegant furniture. All these rooms boast breathtaking view of the Bay of Naples, Castel dell'Ovo and Borgo Marinari, a picturesque fishing village. The spacious bathrooms are decorated with luxurious green Guatemalan marble.
- The spacious Junior Suites are equipped with one king-size bed and they are open plan rooms with living area. The Junior suites are individually decorated and they are elegantly and comfortably appointed in warm colours with Murano glass chandeliers. The Junior suites offer balcony with beautiful view of the sea. The elegant marble bathrooms are equipped with a whirlpool bathtub for two persons.
- The Senior Suites are individually and elegantly decorated with Murano glass chandeliers. These suites consist of a luxurious bedroom, a spacious and elegant living room and a balcony with panoramic view. The elegant marble bathroom offer a Jacuzzi.
- The spacious and elegant Presidential Suite consists of separate bedroom, decorated in liberty style and a large living room, decorated with antique furniture, precious original paintings from the eighteenth century, Murano glass chandeliers and with magnificent seaview. The marble tiled bathroom offer a giant jacuzzi.
- The Suite Partenope is the most elegant and exclusive suite of the hotel. This majestic and romantic penthouse apartment has a size of 150 squaremetres (1,615 square feet) and consists of two bedrooms, a spacious living room with brethtaking view of the Gulf of Naples and three bathrooms with precious marble. The terrace has a size of 80 squaremetres (861 square feet) and boasts a magnificent view.